Undifferentiated sinonasal carcinomas and even more tumors of salivary glands are Dr Uro-Coste’s favorite domains of hyperspecialization since 1993. In addition to the routine cases, Dr Uro-Coste expertises around 200 second review cases per year including cases from the French national cancer network REFCOR.
To bring more security to the diagnosis, The Oncopole was among the first to use the published molecular signatures for diagnostic purpose. It develops molecular tests for these tumors and has a large availability of FISH probes including MYB, PLAG1, MAML2, ETV6, EWSR1, EBER and HR HPV.
The Oncopole masters key antibodies reactivities in these domains: NUT, INI/BAF47, p16, mammaglobin, HER2, androgen receptors etc... When necessary, targeted sequencing including IDH2 and PRKD1 hotspot mutations is also available in their lab. They also develop RNA sequencing methods to identify gene fusions. All techniques are available on FFPE specimen.